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Directions for Use: INITIAL (4-6 WEEKS): WEIGHT | 31 to 60 lbs | 61 to 100 lbs | 101 +Over AMOUNT | 2 | 4 | 5 FREQUENCY: Daily MAINTENANCE (AFTER INTIAL PERIOD): WEIGHT | 31 to 60 lbs | 61 to 100 lbs | 101 +Over AMOUNT | 1 | 2 | 3 FREQUENCY: Daily If giving more than 1 chew daily, divide between AM and PM Ingredient Highlights GlycOmega Green-Lipped Mussel (Perna canaliculus) is the foundation of our formula and natures perfect blend for joint support

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Further evidence for this comes from the knowledge that GSTP can selectively inhibit C -Jun phosphorylation by JNK, preventing apoptosis